{"id":173,"date":"2022-10-03T11:30:37","date_gmt":"2022-10-03T11:30:37","guid":{"rendered":"https:\/\/theragent.com\/?page_id=173"},"modified":"2023-07-29T00:07:29","modified_gmt":"2023-07-29T00:07:29","slug":"covina-discovery-lab","status":"publish","type":"page","link":"https:\/\/theragent.com\/facility\/covina-discovery-lab\/","title":{"rendered":"Covina Discovery Lab"},"content":{"rendered":"<header id=\"image-header-block-block_fcb8cdc0d02974a719fb6b3e7e03d29d\" class=\"image-header-block style-text-left-angle-bg height-default\">\n    <div class=\"bg\" style=\"background-image:url(https:\/\/theragent.com\/wp-content\/uploads\/2022\/10\/red-lab-2000x1153.jpg); background-position: 50% 50%;\"><\/div>\n    <div class=\"text\"><div>\n        <div>\n            <div class=\"pre-headline\">Covina Discovery Lab<\/div>            <h2>It starts at the bench.<\/h2>                        <p>Theragent houses a dedicated Process &#038; Analytical Science development center at our Covina Discovery Lab. This facility is the research and development hub where our scientists collaborate and problem-solve on the bench. Here we perform R&#038;D for early- stage client product development; Process Science for early to late- stage optimization and scale up; and Analytical Sciences for method validation, product characterization, and lifecycle management. Covina is the gateway to partner early with our clients in your drug development pipeline, ultimately leading to efficient and effective lab tech transfer to our Arcadia cGMP facility.<\/p>\n                    <\/div>\n            <\/div><\/div>\n<\/header>\n\n\n<h3 class=\"wp-block-heading has-text-align-center\">Covina Discovery Lab Capabilities<\/h3>\n\n\n\n<div class=\"wp-block-columns is-list is-layout-flex wp-container-core-columns-is-layout-1 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul>\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-red-color\">Production of high titer viral particles for transduction:<\/mark><\/strong> Lentivirus (2nd\/3rd Generation, VSV-G Pseudotyped); \u03b3-retrovirus (VSV-G Pseudotyped)<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-red-color\">Quantification and validation of viral titers:<\/mark><\/strong> p24 ELISA; Target cell transduction and flow cytometric analysis; RT qPCR<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-red-color\">Cell line generation:<\/mark><\/strong> transcriptional reporters; target cell lines for cytotoxicity assays; cloning; stable cell line development<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul>\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-red-color\">Process development:<\/mark><\/strong> primary T cell culture and engineering; PBMC and T cell isolation; T cell transduction; in vitro T cell expansion<\/li>\n\n\n\n<li><strong><mark style=\"background-color:rgba(0, 0, 0, 0)\" class=\"has-inline-color has-red-color\">Proof of Concept demonstration studies:<\/mark><\/strong> Phenotype and CAR-expression; T cell activation; T cell cytotoxicity; cytokine release<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n<article id=\"facts-block-block_648f1cb524c54a2af24637b2219aafa5\" class=\"facts-block\">\n    <div class=\"facts-bg\"><svg class=\"svg-icon logo-mark\" width=\"24\" height=\"24\" aria-hidden=\"true\" role=\"img\" focusable=\"false\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\" xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 64 64\"><g><path d=\"M7,32.8c0-1.7-1.3-3-3.1-3c-1.7,0-3.1,1.3-3.1,2.9c0,1.6,1.3,3,3.1,3C5.5,35.7,7,34.4,7,32.8z\"\/><path d=\"M45.9,23.6c0.5-0.5,0.9-1.1,1-1.8l8.8-1.4c0.2,0.4,0.7,0.8,1.2,0.9c1.2,0.3,2.4-0.3,2.7-1.4c0.3-1.1-0.4-2.2-1.5-2.6 c-1.2-0.3-2.4,0.3-2.7,1.4c0,0,0,0.1,0,0.1l-8.8,1.4c-0.1-0.3-0.3-0.6-0.6-0.9c-0.2-0.2-0.4-0.4-0.7-0.5l2.2-7.5c0.1,0,0.2,0,0.3,0 c1.2-0.3,1.9-1.4,1.6-2.5c-0.3-1.1-1.4-1.8-2.6-1.5c-1.2,0.3-1.9,1.4-1.6,2.5c0.1,0.5,0.4,0.9,0.8,1.1l-2.2,7.4 c-0.8,0-1.6,0.3-2.2,0.9c-1.2,1.1-1.3,3-0.1,4.2C42.7,24.7,44.7,24.8,45.9,23.6z\"\/><path d=\"M8.6,20.7c0.5-0.1,0.9-0.4,1.2-0.7l7.8,2.1c0,0.7,0.2,1.5,0.9,2.1c1.2,1.2,3.1,1.2,4.4,0.1c1.2-1.1,1.2-3,0.1-4.2 c-0.5-0.5-1.2-0.8-1.9-0.9l-1.4-8.4c0.5-0.2,0.8-0.7,1-1.2c0.3-1.1-0.3-2.2-1.4-2.5c-1.2-0.3-2.4,0.3-2.7,1.4 c-0.3,1.1,0.3,2.2,1.5,2.6c0,0,0.1,0,0.1,0l1.4,8.4c-0.3,0.1-0.6,0.3-0.9,0.6c-0.2,0.2-0.4,0.4-0.5,0.6l-7.8-2.1c0-0.1,0-0.2,0-0.3 c-0.3-1.1-1.4-1.8-2.6-1.5C6.4,17,5.7,18.1,6,19.2C6.3,20.3,7.5,20.9,8.6,20.7z\"\/><path d=\"M19.1,41.8c-0.5,0.5-0.8,1.2-0.9,1.9L9.4,45c-0.3-0.4-0.7-0.7-1.2-0.9c-1.2-0.3-2.4,0.3-2.7,1.4c-0.3,1.1,0.3,2.2,1.5,2.5 c1.1,0.3,2.3-0.3,2.6-1.4c0,0,0-0.1,0-0.1l8.8-1.4c0.2,0.3,0.3,0.6,0.6,0.8c0.2,0.2,0.4,0.4,0.6,0.5l-2.2,7.4c-0.1,0-0.2,0-0.3,0.1 c-1.2,0.3-1.9,1.4-1.6,2.5c0.3,1.1,1.5,1.8,2.6,1.5c1.2-0.3,1.9-1.4,1.6-2.5c-0.1-0.5-0.4-0.9-0.8-1.1l2.2-7.5 c0.8,0,1.6-0.3,2.2-0.8c1.2-1.1,1.2-3,0.1-4.2C22.4,40.7,20.4,40.7,19.1,41.8z\"\/><path d=\"M56.4,44.8c-0.5,0.1-0.9,0.4-1.2,0.7l-7.8-2.1c0-0.7-0.3-1.5-0.9-2.1c-1.2-1.2-3.1-1.2-4.4-0.1c-1.2,1.1-1.2,3,0,4.2 c0.5,0.6,1.2,0.8,1.9,0.9l1.4,8.4c-0.5,0.3-0.8,0.7-1,1.2c-0.3,1.1,0.3,2.2,1.4,2.6c1.2,0.3,2.4-0.3,2.7-1.4 c0.3-1.1-0.3-2.2-1.5-2.5c0,0-0.1,0-0.1,0l-1.4-8.4c0.3-0.2,0.6-0.3,0.9-0.6c0.2-0.2,0.4-0.4,0.5-0.6l7.8,2.1c0,0.1,0,0.2,0,0.3 c0.3,1.1,1.4,1.8,2.6,1.5c1.2-0.3,1.9-1.4,1.6-2.5C58.7,45.2,57.6,44.5,56.4,44.8z\"\/><path d=\"M32.5,22.6c-2.1,0-3.7,1.6-3.7,3.5c0,2,1.7,3.5,3.7,3.5c2,0,3.7-1.6,3.7-3.5C36.3,24.2,34.6,22.6,32.5,22.6z\"\/><path d=\"M42.6,32.7c0,2,1.7,3.5,3.7,3.5c2,0,3.7-1.6,3.7-3.5c0-1.9-1.7-3.5-3.7-3.5C44.2,29.2,42.6,30.8,42.6,32.7z\"\/><path d=\"M17.7,29.2c-2,0-3.7,1.6-3.7,3.5c0,2,1.7,3.5,3.7,3.5c2.1,0,3.7-1.6,3.7-3.5C21.4,30.8,19.8,29.2,17.7,29.2z\"\/><path d=\"M32.5,35.7c-2.1,0-3.7,1.6-3.7,3.5c0,1.9,1.7,3.5,3.7,3.5c2,0,3.7-1.6,3.7-3.5C36.3,37.3,34.6,35.7,32.5,35.7z\"\/><path d=\"M31.5,7.5l0,3.5c-0.2,0-0.3,0.1-0.5,0.2c-1.4,0.7-1.9,2.4-1.2,3.7c0.8,1.3,2.6,1.8,4,1.1c1.4-0.7,1.9-2.4,1.1-3.8 c-0.4-0.7-1-1.1-1.7-1.3l0.1-3.4c0.3-0.1,0.6-0.2,0.9-0.3c1.6-0.8,2.1-2.7,1.2-4.2c-0.9-1.5-2.8-2-4.4-1.2 c-1.6,0.8-2.2,2.7-1.3,4.2C30.1,6.8,30.8,7.3,31.5,7.5z\"\/><path d=\"M60.2,29.8c-1.7,0-3.1,1.3-3.1,2.9c0,1.6,1.3,3,3,3c1.7,0,3.1-1.3,3.2-2.9C63.3,31.1,61.9,29.8,60.2,29.8z\"\/><path d=\"M32.5,46.9c-2,0-3.6,1.5-3.6,3.4c0,1.9,1.6,3.4,3.6,3.4c1.9,0,3.6-1.5,3.6-3.4C36.1,48.4,34.5,46.9,32.5,46.9z\"\/><path d=\"M32.5,56.3c-1.8,0-3.3,1.4-3.3,3.1c0,1.7,1.4,3.1,3.3,3.1c1.8,0,3.3-1.4,3.3-3.1C35.8,57.7,34.3,56.3,32.5,56.3z\"\/><\/g><\/svg><\/div>\n    <div class=\"facts-content\">\n        <header>\n            <h3>Covina Facility Fast Facts<\/h3>        <\/header>\n        <div>\n                            <section>\n                        <div class=\"stat\">6,000 sq. ft.<\/div>\n                        <div class=\"supporting\">laboratory space<\/div>\n                    <\/section>\n                                    <section>\n                        <div class=\"stat\">2,000 sq. ft.<\/div>\n                        <div class=\"supporting\">overflow warehouse space for non-GMP material<\/div>\n                    <\/section>\n                                    <section>\n                        <div class=\"stat\">Pilot scale clean&nbsp;room<\/div>\n                        <div class=\"supporting\">for pre-clinical GLP batch development<\/div>\n                    <\/section>\n                        <\/div>\n    <\/div>\n<\/article>\n\n\n<div style=\"height:50px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n\n\n\n<h3 class=\"wp-block-heading has-text-align-center\">Lab Equipment<\/h3>\n\n\n\n<div class=\"wp-block-columns is-list is-layout-flex wp-container-core-columns-is-layout-2 wp-block-columns-is-layout-flex\">\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul>\n<li>3x BSCs(Class II A2)<\/li>\n\n\n\n<li>6 x CO2 Incubators<\/li>\n\n\n\n<li>30x 6\u2019 Lab Benches<\/li>\n\n\n\n<li>LN2 storage and cell bank<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul>\n<li>LCMS<\/li>\n\n\n\n<li>Spectrophotometer<\/li>\n\n\n\n<li>Miltenyi CliniMACS Prodigy\u00ae<\/li>\n\n\n\n<li>HPLC<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul>\n<li>Live-Cell Analysis<\/li>\n\n\n\n<li>Sepax C-Pro<\/li>\n\n\n\n<li>FACS (Attune and Cytoflex)<\/li>\n\n\n\n<li>qPCR, ddPCR<\/li>\n<\/ul>\n<\/div>\n\n\n\n<div class=\"wp-block-column is-layout-flow wp-block-column-is-layout-flow\">\n<ul>\n<li>Barkey plasmatherm<\/li>\n\n\n\n<li>Luminex flow cytometer<\/li>\n\n\n\n<li>Incucyte\u00ae Live-Cell Analysis<\/li>\n<\/ul>\n<\/div>\n<\/div>\n\n\n\n<p class=\"has-text-align-center\"><strong>Interested in Clinical Production? <a href=\"\/facility\/arcadia-cgmp-facility\/\">See Our cGMP Facility<\/a><\/strong><\/p>\n\n\n\n<div style=\"height:90px\" aria-hidden=\"true\" class=\"wp-block-spacer\"><\/div>\n","protected":false},"excerpt":{"rendered":"<p>Theragent houses a dedicated Process &#038; Analytical Science development center at our Covina Discovery Lab. This facility is the research and development hub where our scientists collaborate<br \/>\nand problem-solve on the bench. Here we perform R&#038;D for early- stage client product development; Process Science for early to late- stage optimization and scale up; and Analytical Sciences for method validation, product characterization, and lifecycle management. Covina is the gateway to partner early with our clients in your drug development pipeline, ultimately leading to efficient and effective lab tech transfer to our Arcadia cGMP facility.<\/p>\n","protected":false},"author":1,"featured_media":452,"parent":23,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"footnotes":""},"acf":[],"_links":{"self":[{"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/pages\/173"}],"collection":[{"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/comments?post=173"}],"version-history":[{"count":15,"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/pages\/173\/revisions"}],"predecessor-version":[{"id":688,"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/pages\/173\/revisions\/688"}],"up":[{"embeddable":true,"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/pages\/23"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/media\/452"}],"wp:attachment":[{"href":"https:\/\/theragent.com\/wp-json\/wp\/v2\/media?parent=173"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}