Cell Types We Support

Stem Cells: MSC

Mesenchymal stem cells (MSCs) are a type of multipotent stromal cells capable of differentiating into bone, cartilage, muscle, and fat cells. MSCs are known to have immune modulation effects as well as antimicrobial properties.

The Approach

MSCs can function as therapeutic modalities in both tissue regeneration and immune modulation due to their ability to differentiate into different tissue types, while also releasing immunomodulating proteins, surface markers, and antimicrobial peptides. The genome of MSCs can be edited using viral vectors encoded for genes of interest to implement a more robust therapeutic response. For this reason, MSCs are being investigated as cellular therapies.

The Challenge

MSCs are inherently heterogeneous, coming from different donors and different tissue types. Sorting for the appropriate subset of MSCs for the desired therapeutic application can be challenging. Characterizing and maintaining the stemness of MSCs, while also expanding the cells for clinical use, presents an additional challenge.

At Theragent, we bring to bear the appropriate clean room equipment to execute your MSC expansion project.

Over 400 clinical trials have involved the use of MSC therapies. MSCs are being tested in regenerative medicine, autoimmune disorders, inflammatory diseases, oncology, and graft versus host disease.

Current research is ongoing to genetically alter MSCs to improve their stemness stability. These challenges are mitigated by having a GMP-compliant facility capable of stem cell isolation, expansion, and banking. At Theragent, we bring to bear the appropriate clean room equipment to execute your MSC expansion project. We offer both analytical method development services, as well as the execution of analytical methods in-house, drastically shortening production timelines, while ensuring the appropriate quality control. Reach out to us to learn more about we can accelerate your MSC project from pre-clinical through clinical trials.

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